P-88 Epithelial-to-mesenchymal transition: An emerging prognostic tool in resectable pancreatic cancer, a retrospective study

Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of global cancer death. Epithelial-to-mesenchymal transition (EMT) described as downregulation in epithelial markers such E-cadherin (E-cad) with increased expression mesenchymal Vimentin (Vim). This process one triggers early progression and metastasis PDAC. Our study aims to determine levels E-cad Vim well value EMT a predictor overall survival (OS) disease-free (DFS) among patients resectable retrospective involving diagnosed PDAC at American University Beirut Medical Center between January 1, 2005 June 30, 2019. We are reporting data immunohistochemical analysis 137 patients. Evaluation was done document percentage stained cells Vim, staining intensity follows: 0:no stain, 1:weak, 2:moderate, 3:strong. The score calculated based on E-cad-stained 0: 25-50%, 3:>50-75%, 4:>75%. multiplied by stain intensity. Finally, score; low (1-3) 1: High (≥4). Vim-stained defined Low ( 10%). Between 2019, total 541 were pancreatic cancer, out which enlisted have Two cases excluded because they lacked paraffin blocks sufficient tumor tissue for staining. A multivariable revealed that only associated poor OS DFS. Out 135 Patients, 28 (20.7%) had 107 (79.3%) high expression. 38 (28.1%) 97 (71.9%) 11 (8.2%) low/Vim high. Median 25.5 months while DFS 13.1 months. 24.6 13 versus all other (P=0.682 0.382), respectively. 17 10.1 26.6 16.5 (P=0.011 0.007), 12.6 9.5 25.8 14.6 (P=0.039 P=0.029), showed overexpression phenomenon strongly cancer.